Did you know more than 15 million Americans suffer from hyperhidrosis — or nearly 5% of the population? New data reveals that more Americans than previously estimated live with severe excessive sweating, most commonly occurring in the underarm area.

I dealt with excessive underarm sweating for over a decade before I was diagnosed with axillary hyperhidrosis and set out to create my own solution, the Thompson Tee.

And the research shows I’m not alone. In fact, 49% of those who sweat excessively have not discussed it with a doctor because they don’t think hyperhidrosis is a medical condition or that treatment options exist. Sound familiar?

Whether you’ve been diagnosed with hyperhidrosis or not, millions of people need an effective solution to moderate to severe underarm sweat. For most people, expensive and life-threatening surgeries and procedures just aren’t realistic solutions.

To meet the demand for non-invasive solutions, more pharmaceutical companies are releasing hyperhidrosis treatments to help alleviate the life-altering effects of excessive underarms sweating.

New Hyperhidrosis Drugs

We’ve written about prescription drugs for hyperhidrosis (called anticholinergics) in the past and common side effects. These neurotransmitter-blocking drugs — originally designed to treat asthma, incontinence, depression, COPD and other gastrointestinal issues — are now used to treat excessive sweating because they dry out the body.

Dermira and TheraVida are two new hyperhidrosis drugs that target excessive sweating and have recently been put through clinical trials to test their effectiveness. Here’s an overview of what they are and the results of the trials:

Dermira DRM04


Dermira is a biopharmaceutical company focused on developing drugs for dermatologic diseases. The company’s hyperhidrosis drug, DRM04, is a topical anticholinergic that users apply directly to the skin.

In recent clinical studies, patients applied the topical solution once daily for four weeks. Compared to those who received the placebo, patients reported significant improvements in the severity of their sweat and quality of life with only mild to moderate side effects. Of the patients taking Dermira, 72-77% experienced at least a 50% reduction in their measured sweating volume.

Next, Dermira plans to conduct studies that assess DRM04’s long-term safety in patients using it for at least a year. Based on those results, Dermira could apply for FDA approval by the end of 2017. We're eager to see the results and how Dermira plans to counteract the mild to severe side effects of anticholinergics.

TheraVida THVD-102


TheraVida is a specialty pharmaceutical company engineering drugs for primary and secondary hyperhidrosis, including THVD-102. This oral anticholinergic hybrid is combined with another medicine to combat the side effects of anticholinergics. Because the pill works throughout the body, it has been shown to limit overall sweating and reduce dry mouth when taken twice per day.

The drugs used in THVD-102 include the oral medicine oxybutynin and a delayed-release version of pilocarpine — which combats side effects of oxybutynin such as dry mouth. However, what makes TheraVida unique is its technology, which delays the release of custom doses of pilocarpine to reduce the frequency and severity of dry mouth.

Although TheraVida has tested its drug technology in multiple human trials, the long-term effects are still unknown.

Find the Right Hyperhidrosis Solution for You

Spending countless hours researching and testing failed products, I know the stress involved in dealing with excessive sweat and the hopelessness that every so-called solution is too good to be true. My friend and co-founder Randy Choi went as far as to get his sweat glands removed to overcome hyperhidrosis. But getting ETS surgery only left Randy with an even worse sweating problem on his chest and torso. After seeing the hardship he went through, I knew I needed to create a more practical solution.

That’s why I developed patented sweat proof undershirts and continue to research new solutions to hyperhidrosis all the time. By wearing Thompson Tees, I am finally able to forget about underarm sweat. When you stop fearing nasty sweat marks, hyperhidrosis no longer dictates your life.

If you’re looking for other solutions to hyperhidrosis, we encourage you to try a shirt risk-free or check out our comprehensive list of hyperhidrosis treatment options to find the right one for you.

Have you tried hyperhidrosis drugs? We'd love to hear about your experience.